Dihydrotestosterone (DHT) – The devil in the wood pile
Dihydrotestosterone or DHT as it is known is a very potent hormone in the humane body. This hormone DHT is responsible for giving man his male characteristics when he is just a fetus in his mother’s womb. To put things in the simplest of ways, all of us start out in the womb as females, a status decided on by nature. It is during the sixth week of pregnancy that DHT begins to form in the fetus by testosterone, the male hormone, combining with an enzyme called 5 alpha reductase. It is this DHT that stimulates the growth of the male sex organs and stems the growth of the female genitalia. Now just imaging what would happen if this DHT were to be a scarce commodity during this crucial stage of sex determination in the fetus!
The anomalies of DHT deficiency
The result of a deficiency of Dihydrotestosterone in the fetus stage will result in abnormal formation of male sex organs and will produce an infant which will be neither this way nor that, and if the male genitalia are fully formed then there may just be a lack of libido and probably complete sterility. Let us understand how this happens. Because males with a deficiency of Dihydrotestosterone are born with ambiguous genitalia, this condition is better known as ‘Pseudohermaphroditism’ the clinical abnormalities of this condition will range from infertility to underdeveloped male with ‘Hypospadias’ to predominantly developed female external genitalia. The uterus and fallopian tubes in this case are absent because of the normal secretion of the ‘m